Fri May 06 2022

16 articles - From Saturday Apr 30 2022 to Friday May 06 2022

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Guidelines

Guidelines, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews


Original articles

RCT, clinical trials, retrospective studies, etc…

Arthritis Res Ther

Associated factors with poor treatment response to initial glucocorticoid therapy in patients with adult-onset Still's disease.

A higher WBC count but not thrombocytopenia, hyperferritinemia, and mSFS at baseline was a significant prognostic factor for poor treatment outcome at week 4 in this retrospective cohort of AOSD patients. Our findings provide important information for determining the initial treatment strategy of newly-diagnosed AOSD.

Pubmed   Journal   ReadQx   PMC

Autologous hematopoietic stem cell transplantation promotes connective tissue remodeling in systemic sclerosis patients.

Our results suggest that the therapeutic effects of AHSCT on skin fibrosis are related to changes in molecules associated with connective tissue maintenance and inflammation in SSc.

Pubmed   Journal   ReadQx   PMC

Clinical heterogeneity of ocular Behçet's syndrome versus intestinal Behçet's syndrome: a cross-sectional study from Shanghai Behçet's syndrome database.

Ocular BS was more prevalent in male patients and more likely to manifest with erythema nodosum and vascular involvement, while intestinal BS tends to have fever and hematologic disorders with higher inflammation markers. Ocular BS and intestinal BS are two distinct clinical phenotypes and very rarely overlapped.

Pubmed   Journal   ReadQx   PMC

Effects of local cryotherapy on systemic endothelial activation, dysfunction, and vascular inflammation in adjuvant-induced arthritis (AIA) rats.

In the AIA model, local cryotherapy reduced systemic endothelial activation, immune cell infiltration, and endothelial dysfunction. Mechanistically, the reduction of circulating levels of IL-17A appears as the possible link between joint cooling and the remote vascular effects.

Pubmed   Journal   ReadQx   PMC

Elevation of a-1,3 fucosylation promotes the binding ability of TNFR1 to TNF-a and contributes to osteoarthritic cartilage destruction and apoptosis.

The elevation of a-1,3 fucosylation is not only a characteristic of OA but also impacts the OA pathological process. Our work provides a new positive feedback loop of "inflammation conditions/TNF-a/FUT10/a-1,3 fucosylation of TNFR1/NF-B and P38/JNK-MAPK pathways/proinflammatory processes" that contributes to ECM degradation and chondrocyte apoptosis.

Pubmed   Journal   ReadQx   PMC

PTH (1-34) enhances the therapeutic effect of bone marrow mesenchymal stem cell-derived exosomes by inhibiting proinflammatory cytokines expression on OA chondrocyte repair in vitro.

Exo PTH increased the migration, proliferation, and chondral matrix formation of OA chondrocytes in vitro. In OA chondrocyte therapy, the potential mechanism of Exo PTH might involve the inhibition of production of proinflammatory cytokines. Although the two types of exosomes had some similar effects, most effects of Exo PTH were better than those of Exo BMSC , so Exo PTH may have a better ability to alleviate OA.

Pubmed   Journal   ReadQx   PMC

The angiopoietin-like protein 4, apolipoprotein C3, and lipoprotein lipase axis is disrupted in patients with rheumatoid arthritis.

The axis consisting in ANGPTL4, ApoC3, and LPL is disrupted in patients with RA. ANGPTL4 serum levels are positively and independently associated with a higher cIMT in RA patients.

Pubmed   Journal   ReadQx   PMC

The compound LG283 inhibits bleomycin-induced skin fibrosis via antagonizing TGF-ß signaling.

The LG283 compound exhibits antagonistic activity on fibrosis and vascular injury through inhibition of TGF-ß/Smad/Snail mesenchymal transition pathways and thus, may be a candidate therapeutic for the treatment of SSc. Although the involvement of EMT in the pathogenesis of SSc remains unclear, the screening of EMT regulatory compounds may be an attractive approach for SSc therapy.

Pubmed   Journal   ReadQx   PMC

Arthritis Rheumatol

Antigen-experienced CXCR5- CD19low B cells are plasmablast precursors expanded in SLE.

Our data suggest that CXCR5 - CD19 low B cells are precursors of plasmablasts, thus co-targeting this subset may have therapeutic value in SLE.

Pubmed   Journal   ReadQx 

Comparative genetic analysis of psoriatic arthritis and psoriasis for the discovery of genetic risk factors and risk prediction modelling.

Key biological pathways associated with PsA were identified but the investigation of risk classification revealed modest utility in the available datasets, possibly because a large number of the PsC patients were receiving treatments that are also effective in PsA; future predictive models of PsA should be tested in PsC patients recruited from primary care.

Pubmed   Journal   ReadQx 

Genomic risk score for advanced osteoarthritis in older adults.

PRSs have the potential to improve prevention of severe knee and hip osteoarthritis by providing a personalized approach and identifying individuals who may benefit from early intervention.

Pubmed   Journal   ReadQx 

Immunogenicity and Safety of Standard and Third Dose SARS-CoV-2 Vaccination in Patients on Immunosuppressive Therapy.

IMID-patients had an attenuated response to standard vaccination as compared to healthy controls. A third vaccine dose was safe and resulted in serological response in most patients. These data facilitate identification of patient groups at risk of attenuated vaccine response, and support administering a third vaccine dose to poorly-responding IMID-patients.

Pubmed   Journal   ReadQx 


Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link


Letters&Replies

Letters to the editors and authors’ replies

Ann Rheum Dis

Correspondence on 'No efficacy of anti-IL-23 therapy for axial spondyloarthritis in randomised controlled trials but in post-hoc analyses of psoriatic arthritis-related 'physician-reported spondylitis'?' by Braun and Landewé.

Pubmed   Journal   ReadQx 


Others

all remaining publications eg case reports, images of the month, etc…

Ann Rheum Dis

Progressive increase in time to referral and persistently severe clinical presentation over the years in autoantibody-negative patients with rheumatoid arthritis in the setting of an early arthritis clinic.

Pubmed   Journal   ReadQx 

Response to: Correspondence on 'No efficacy of anti-IL-23 therapy for axial spondyloarthritis in randomised controlled trials but in post hoc analyses of psoriatic arthritis-related 'physician-reported spondylitis'?' by Braun and Landewé.

Pubmed   Journal   ReadQx 

Arthritis Care Res (Hoboken)

A Rare Manifestation of a Rare Disease: the importance of thinking outside the box in a complex dermatomyositis case.

Pubmed   Journal   ReadQx