16 articles - From Saturday Apr 30 2022 to Friday May 06 2022
Guidelines, position statements, white papers, technical reviews, consensus statements, etc…
meta-analyses and systematic reviews
RCT, clinical trials, retrospective studies, etc…
| Arthritis Res Ther |
Associated factors with poor treatment response to initial glucocorticoid therapy in patients with adult-onset Still's disease. A higher WBC count but not thrombocytopenia, hyperferritinemia, and mSFS at baseline was a significant prognostic factor for poor treatment outcome at week 4 in this retrospective cohort of AOSD patients. Our findings provide important information for determining the initial treatment strategy of newly-diagnosed AOSD. |
Autologous hematopoietic stem cell transplantation promotes connective tissue remodeling in systemic sclerosis patients. Our results suggest that the therapeutic effects of AHSCT on skin fibrosis are related to changes in molecules associated with connective tissue maintenance and inflammation in SSc. |
Clinical heterogeneity of ocular Behçet's syndrome versus intestinal Behçet's syndrome: a cross-sectional study from Shanghai Behçet's syndrome database. Ocular BS was more prevalent in male patients and more likely to manifest with erythema nodosum and vascular involvement, while intestinal BS tends to have fever and hematologic disorders with higher inflammation markers. Ocular BS and intestinal BS are two distinct clinical phenotypes and very rarely overlapped. |
Effects of local cryotherapy on systemic endothelial activation, dysfunction, and vascular inflammation in adjuvant-induced arthritis (AIA) rats. In the AIA model, local cryotherapy reduced systemic endothelial activation, immune cell infiltration, and endothelial dysfunction. Mechanistically, the reduction of circulating levels of IL-17A appears as the possible link between joint cooling and the remote vascular effects. |
Elevation of a-1,3 fucosylation promotes the binding ability of TNFR1 to TNF-a and contributes to osteoarthritic cartilage destruction and apoptosis. The elevation of a-1,3 fucosylation is not only a characteristic of OA but also impacts the OA pathological process. Our work provides a new positive feedback loop of "inflammation conditions/TNF-a/FUT10/a-1,3 fucosylation of TNFR1/NF- |
PTH (1-34) enhances the therapeutic effect of bone marrow mesenchymal stem cell-derived exosomes by inhibiting proinflammatory cytokines expression on OA chondrocyte repair in vitro. Exo PTH increased the migration, proliferation, and chondral matrix formation of OA chondrocytes in vitro. In OA chondrocyte therapy, the potential mechanism of Exo PTH might involve the inhibition of production of proinflammatory cytokines. Although the two types of exosomes had some similar effects, most effects of Exo PTH were better than those of Exo BMSC , so Exo PTH may have a better ability to alleviate OA. |
The angiopoietin-like protein 4, apolipoprotein C3, and lipoprotein lipase axis is disrupted in patients with rheumatoid arthritis. The axis consisting in ANGPTL4, ApoC3, and LPL is disrupted in patients with RA. ANGPTL4 serum levels are positively and independently associated with a higher cIMT in RA patients. |
The compound LG283 inhibits bleomycin-induced skin fibrosis via antagonizing TGF-ß signaling. The LG283 compound exhibits antagonistic activity on fibrosis and vascular injury through inhibition of TGF-ß/Smad/Snail mesenchymal transition pathways and thus, may be a candidate therapeutic for the treatment of SSc. Although the involvement of EMT in the pathogenesis of SSc remains unclear, the screening of EMT regulatory compounds may be an attractive approach for SSc therapy. |
| Arthritis Rheumatol |
Comparative genetic analysis of psoriatic arthritis and psoriasis for the discovery of genetic risk factors and risk prediction modelling. Key biological pathways associated with PsA were identified but the investigation of risk classification revealed modest utility in the available datasets, possibly because a large number of the PsC patients were receiving treatments that are also effective in PsA; future predictive models of PsA should be tested in PsC patients recruited from primary care. |
Immunogenicity and Safety of Standard and Third Dose SARS-CoV-2 Vaccination in Patients on Immunosuppressive Therapy. IMID-patients had an attenuated response to standard vaccination as compared to healthy controls. A third vaccine dose was safe and resulted in serological response in most patients. These data facilitate identification of patient groups at risk of attenuated vaccine response, and support administering a third vaccine dose to poorly-responding IMID-patients. |
Plenty of the editorials are available as full text through the publisher website using the provided link
Letters to the editors and authors’ replies
| Ann Rheum Dis |
all remaining publications eg case reports, images of the month, etc…
| Ann Rheum Dis |
| Arthritis Care Res (Hoboken) |